Table 6. Clinical status and ICAM-1 genotypic frequencies in 595 oral cancer patients.
Variable | rs3093030 | rs5491 | rs281432 | rs5498 | ||||||||
CC (N = 384) | CT+TT (N = 211) | p value | AA (N = 537) | AT+TT (N = 58) | p value | CC (N = 332) | CG+GG (N = 263) | p value | AA (N = 329) | AG+GG (N = 266) | p value | |
Clinical Stage | ||||||||||||
Stage I/II | 168 (43.8%) | 93 (44.1%) | 0.939 | 226 (42.1%) | 35 (60.3%) | 0.008 * | 131 (39.5%) | 130 (49.4%) | 0.015 * | 136 (41.3%) | 125 (47.0%) | 0.167 |
Stage III/IV | 216 (56.2%) | 118 (55.9%) | 311 (57.9%) | 23 (39.7%) | 201 (60.5%) | 133 (50.6%) | 193 (58.7%) | 141 (53.0%) | ||||
Tumor size | ||||||||||||
≤T2 | 239 (62.2%) | 124 (58.8%) | 0.406 | 322 (60.0%) | 41 (70.7%) | 0.112 | 193 (58.1%) | 170 (64.6%) | 0.106 | 195 (59.3%) | 168 (63.2%) | 0.334 |
>T2 | 145 (37.8%) | 87 (41.2%) | 215 (40.0%) | 17 (29.3%) | 139 (41.9%) | 93 (35.4%) | 134 (40.7%) | 98 (36.8%) | ||||
Lymph node metastasis | ||||||||||||
No | 242 (63.0%) | 137 (64.9%) | 0.643 | 337 (62.8%) | 42 (72.4%) | 0.146 | 208 (62.7%) | 171 (65.0%) | 0.551 | 206 (62.6%) | 173 (65.0%) | 0.541 |
Yes | 142 (37.0%) | 74 (35.1%) | 200 (37.2%) | 16 (27.6%) | 124 (37.3%) | 92 (35.0%) | 123 (37.4%) | 93 (35.0%) | ||||
Distant metastasis | ||||||||||||
No | 378 (98.7%) | 209 (98.5%) | 0.533 | 529 (98.5%) | 58 (100.0%) | 0.349 | 325 (97.9%) | 262 (99.6%) | 0.069 | 322 (97.9%) | 35 (99.6%) | 0.065 |
Yes | 6 (1.6%) | 2 (0.9%) | 8 (1.5%) | 0 (0%) | 7 (2.1%) | 1 (0.4%) | 7 (2.1%) | 1 (0.4%) |
T2: tumor size >2 cm in the greatest dimension.
P value<0.05 as statistically significant.