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. 2013 Sep 12;8(9):e72549. doi: 10.1371/journal.pone.0072549

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© 2013 Kim et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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To examine organ laterality defects, zebrafish embryos were examined for changes in heart looping. (A) In situ hybridisation (myosin light chain 7; myl7) of both zbbs1 and znphp7.2 morphant embryos at 55 hpf showed defective heart looping. (heart looping to the right (R = normal), without heart looping (mid) and looping to the left (L = inversed)) (B) Whereas the hearts of control embryos showed more than 90% rightward looping, approximately 50% of zBbs1-depleted embryos and (C) 35–75% of zNphp7.2-depleted embryos had situs inversus or mid position of the heart. The numbers in the brackets (n) are the numbers of total embryos which were examined.