Table 2. Univariate analysis of the most relevant clinical and biological parameters.

	Median PFS		P value	Median OS		P value
	Wks			wks
KPS ≤70 versus >70	16	19	n. s.	29	30	n. s.
Age ≤40 yrs versus >40	19	17	n. s.	29	27	n. s.
Age ≤60 yrs versus >60	20	18	n. s.	27	29	n. s.
De novo versus secondary tumor	18	18	n. s.	27	29	n. s.
Tumor volume ≤10.9 mm3 versus >10.9 mm3	29	15	n. s.	37	24	n. s.
Dex <8 mg versus dex ≥8 mg	29	10	0.0001	39	24	0.002
EIAED use versus EIAED free	19	17	n. s.	29	27	n. s.
Distant disease versus no distant disease	9	26	0.0001	19	38	0.0001
Leptomeningeal diss. versus no leptomeningeal diss.	10	20	0.01	19	31	0.01
CD109+CEC ≤41.1/ml versus >41.1/ml	9	20	0.008	23	32	0.03

Abbreviations: dex, dexamethasone; diss, dissemination; EIAED, enzyme-inducing anti-epileptic drugs; wks, weeks; yrs, years.