Table 1. Patients’ demographic and clinical characteristics according to mtDNA haplogroups of the 292 patients of global cohort (first and second cohort combined).
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| Gender male -n (%) | 90 (69.8) | 49 (69.0) | 28 (60.9) | 167 (67.9) | 27 (58.7) | 0.24 |
| Age - median years (p 25-75) | 61 (50-71) | 61 (51-73) | 61 (45-71) | 61 (49-71) | 57 (49-70) | 0.42 |
| Diabetes Mellitus -n (%) | 42 (32.6) | 22 (31.0) | 10 (21.7) | 74 (30.1) | 10 (21.7) | 0.29 |
| COPD -n (%) | 18 (14.0) | 9 (12.7) | 4 (8.7) | 31 (12.6) | 8 (17.4) | 0.35 |
| Ischemic heart disease -n (%) | 15 (11.6) | 7 (9.9) | 5 (10.9) | 27 (11.0) | 3 (6.5) | 0.44 |
| Site of infection | 0.51 | |||||
| - Respiratory -n (%) | 78 (60.5) | 43 (60.6) | 23 (50.0) | 144 (58.5) | 23 (50.0) | |
| - Abdominal -n (%) | 30 (23.3) | 18 (25.3) | 16 (34.8) | 65 (26.4) | 15 (32.6) | |
| - Neurological -n (%) | 3 (2.3) | 1 (1.4) | 1 (2.2) | 5 (2.0) | 1 (2.2) | |
| - Urinary -n (%) | 6 (4.6) | 3 (4.2) | 2 (4.3) | 11 (4.5) | 4 (8.7) | |
| - Skin -n (%) | 4 (3.1) | 2 (2.8) |
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3 (6.5) | |
| - Endocarditis -n (%) | 7 (5.4) | 4 (5.6) | 0 (0) | 11 (4.5) | 0 (0) | |
| - Osteomyelitis -n (%) | 1 (0.8) | 0 (0) | 0 (0) | 1 (0.4) | 0 (0) | |
| Microorganism responsibles | ||||||
| - Unkwon -n (%) | 66 (51.2) | 37 (52.1) | 23 (50.0) | 126 (51.2) | 20 (43.5) | 0.42 |
| - Gram-positive- n (%) | 30 (23.3) | 19 (26.8) | 11 (23.9) | 60 (24.4) | 14 (30.4) | 0.46 |
| - Gram-negative- n (%) | 31 (24.0) | 16 (22.5) | 12 (26.1) | 59 (24.1) | 12 (26.1) | 0.85 |
| - Fungii- n (%) | 5 (3.9) | 2 (2.8) | 1 (2.2) | 8 (3.3) | 0 (0) | 0.36 |
| - Anaerobe- n (%) | 1 (0.8) | 0 (0) | 1 (2.2) | 2 (0.8) | 1 (2.2) | 0.40 |
| Bloodstream infection | 21 (16.3) | 7 (9.9) | 10 (21.7) | 38 (15.4) | 9 (19.6) | 0.51 |
| Empiric antimicrobial treatment adequate | 0.58 | |||||
| - Unkown due to negative cultures- n (%) | 66 (51.2) | 36 (50.7) | 23 (50.0) | 125 (50.8) | 20 (43.5) | |
| - Adequate -n (%) | 49 (38.0) | 30 (42.3) | 22 (47.8) | 101 (41.1) | 20 (43.5) | |
| - Unkown due to antigenuria diagnosis- n (%) | 3 (2.3) | 2 (2.8) | 1 (2.2) | 6 (2.4) | 2 (4.3) | |
| - Inadequate- n (%) | 11 (8.5) | 3 (4.2) | 0 (0) | 14 (5.7) | 4 (8.7) | |
| Betalactamic more aminoglycoside- n (%) | 28 (21.7) | 15 (21.1) | 10 (21.7) | 53 (21.5) | 11 (23.9) | 0.70 |
| Betalactamic more quinolone- n (%) | 61 (47.3) | 40 (56.3) | 27 (58.7) | 128 (52.0) | 22 (47.8) | 0.63 |
| Septic shock- n (%) | 110 (85.3) | 60 (84.5) | 40 (87.0) | 210 (85.4) | 41 (89.1) | 0.65 |
| PaO2/FIO2 ratio - median (p 25-75) | 180 (121-257) | 150 (86-250) | 168 (93-328) | 175 (106-260) | 161 (104-252) | 0.51 |
| Creatinine (mg/dl) - median (p 25-75) | 1.40 (0.85-2.50) | 1.40 (0.90-2.00) | 1.40 (0.70-2.60) | 1.40 (0.90-2.35) | 1.55 (0.97-2.85) | 0.47 |
| Bilirubin (mg/dl) - median (p 25-75) | 1.00 (0.57-2.10) | 0.90 (0.60-1.57) | 0.85 (0.40-1.97) | 0.94 (0.56-1.90) | 1.30 (0.47-1.50) | 0.56 |
| Leukocytes -median*103/mm3 (p 25-75) | 15.2 (9.3-20.3) | 11.9 (6.1-22.0) | 12.8 (8.6-15.7) | 14.0 (8.7-20.0) | 15.9 (11.5-25.7) | 0.89 |
| Lactic acid - median mmol/L (p 25-75) | 2.30 (1.20-4.55) | 2.60 (1.40-4.20) | 2.10 (0.90-4.70) | 2.26 (1.20-4.40) | 2.60 (1.25-4.05) | 0.77 |
| Platelets - median*103/mm3 (p 25-75) | 176 (99-238) | 192 (83-317) | 196 (87-245) | 179 (97-255) | 145 (96-221) | 0.17 |
| INR - median (p 25-75) | 1.40 (1.10-1.69) | 1.29 (1.11-1.56) | 1.33 (1.12-1.52) | 1.33 (1.11-1.59) | 1.24 (1.14-1.51) | 0.56 |
| aPTT - median seconds (p 25-75) | 33 (28-43) | 35 (29-41) | 34 (28-50) | 33 (28-43) | 31 (27-42) | 0.86 |
| Interleukin-6 (pg/ml) - median (p 25-75) | 110 (37-984) | 171 (42-1070) | 301 (45-1075) | 161 (42-1012) | 314 (32-1010) | 0.59 |
| SOFA score - median (p 25-75) | 9 (7-12) | 10 (8-12) | 9 (7-12) | 9 (7-12) | 9 (7-12) | 0.84 |
| APACHE-II score - median (p 25-75) | 20 (16-26) | 20 (15-24) | 21 (16-23) | 20 (16-25) | 20 (15-23) | 0.52 |
| Survivors at 30 days- n (%) | 83 (64.3) | 45 (63.4) | 28 (60.9) | 156 (63.4) | 38 (82.6) | 0.007 |
| Survivors at 6 months- n (%) | 69 (53.5) | 36 (50.7) | 24 (52.2) | 129 (52.4) | 35 (76.1) | 0.002 |
COPD = chronic obstructive pulmonary disease; PaO2/FIO2 = pressure of arterial oxygen/fraction inspired oxygen; INR = International normalized ratio; aPTT = Activated partial thromboplastin time; SOFA = Sepsis-related Organ Failure Assessment; APACHE-II = Acute Physiology and Chronic Health Evaluation-II score. Data are presented as number (percentage) or median (interquartile range)