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. 2013 May 14;2(3):e25025. doi: 10.4161/jkst.25025

Table 2. A selection of potent commercially available JAK inhibitors.

Compound JAK1 JAK2 JAK3 Tyk2 References
AZ960
 -
 3
 9
 -
 57
BMS911543
 356
 1
 73
 66
 218
CEP33779
 ~72
 1.8
 85
 ~1440
 230
JAK inhibitor 1 (JI1,
pyridone 6, CMP6)
 15
 1
 5
 1
 231
NVP-BSK805
 ~32
 0.5
 ~19
 ~11
 232
TG101209 - 6 169 - 233

IC50 values in nM obtained in in vitro kinase assays