Figure 1. The embryonic cuticle phenotype associated with wild-type (A) and loss of JAK-STAT pathway activity (B)—in this case involving the removal of maternally contributed STAT92E. Head skeleton (HS) and posterior spiracles (PS) are both disrupted in pathway mutants. In addition, of the abdominal segments 1 to 8 (a1 to a8) a4 and a5 are missing and a8 reduced in the stat92E mutant. Figure reproduced with permission from reference 49.