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. 2013 Jul 15;2(3):e25686. doi: 10.4161/jkst.25686

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Copyright © 2013 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name jkst-2-e25686-g1.jpg — Figure 1. (A) The anterior tip of the testis hosts the stem cell niche consisting of the hub and CySCs, which are in physical contact with the GSCs. Asymmetric division produces GBs, and transient amplification continues to form spermatogonia (SG) and spermatocytes (SC). (B) JAK-STAT signaling from the hub and CySCs promotes GSC self-renewal and prevents differentiation. GSC intrinsic JAK-STAT activity is required for cell adhesion to the hub. See text for details.