Figure 1. Flow chart of experiment 2.
In experiment 2, animals were exposed to X-Ray irradiation on day 1, 7, 15 and 23. Twenty-four hours after the last irradiation, animals started the 4-week period of bortezomib chemotherapy. The Dynamic Aesthesiometer Test was performed on day 3, 12, 18, 25, 32, 46 and the cytofluorimetric analysis of PB and BM CD45 positive cells on days 26, 40 and 46. On day 46 animals underwent the neurophysiologic analysis and, once euthanized, the sample collection for the neuropathological analysis.
