Figure 4. Mechanical and thermal thresholds, experiment 1.

The mice were tested weekly using the Dynamic Aesthesiometer Test and the incremental hot/cold plate. Bortezomib induced a significant decrease in the mechanical threshold to induce a paw withdrawal at one week, which persisted through week 4 (A). There was no difference between naïve, vehicle and bortezomib-treated mice in the response threshold to a heat (B) and cold (D) stimulus.