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. 2013 Sep 12;8(9):e72995. doi: 10.1371/journal.pone.0072995

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© 2013 Carozzi et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Bortezomib decreased the current perception threshold. The mice were treated with bortezomib or vehicle and tested weekly using the Neurometer to determine the amount of current needed at each frequency (5 Hz, C fibers; 250 Hz, Aδ fibers; 2000 Hz, Aβ fibers) to elicit a paw withdrawal. There was a small but significant decrease in the amount of current needed at 2000 Hz to elicit a paw withdrawal at weeks 1 and 2 of treatment, which resolved back to baseline in weeks 3-4 (A). Bortezomib induced a significant decrease in the amount of current needed at 250 Hz to elicit a paw withdrawal at one week, which persisted through week 4 (B). Bortezomib induced a significant decrease in the amount of current needed at 5 Hz to elicit a paw withdrawal at one week, which persisted through week 4 (C).