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DRG were collected at the time of sacrifice for the immunohistochemical detection of the nuclear transcription factor ATF3. Thick (15 µm) cryostat sections of DRG were collected from vehicle (A) and bortezomib-treated (B) animals. Bortezomib treatment induced a marked nuclear ATF3 expression in DRG sensory neurons (arrows in B). No ATF3-positive nuclei were present in DRG of vehicle-treated mice.
