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. 2013 Sep 12;8(9):e72995. doi: 10.1371/journal.pone.0072995

Figure 11. Bone marrow and peripheral blood and bone marrow white blood cells (WBC) count and FACS analysis, experiment 2.

Figure 11

Black arrows indicate the treatment given to mice, such as the X-ray irradiation doses (350 RAD induction and 100 RAD maintenance), and bortezomib administrations. For each group of animals, the WBC concentration within the BM (A) or peripheral blood (B) is indicated for the corresponding analysis time point. The number of hematopoietic cells in the peripheral blood expressing the pan-leukocyte antigen CD45 is also reported (C). A comparable immune-suppression was observed in both X-Ray and X-Ray-bortezomib-treated animals after the irradiation induction and maintenance doses, as shown by the decreased cellularity and leukopenia in the BM and spleen of irradiated mice, regardless of bortezomib treatment.