TABLE 1.
ACh concentration-response and MLA inhibition concentration-response curve parameters derived from the curve-fitting procedures
CI, confidence interval.
| Receptor (ratio) | ACh |
MLA |
||||
|---|---|---|---|---|---|---|
| EC50 (95% CI) | nH (95% CI) | n | IC50 (95% CI) | −nH (95% CI) | n | |
| m | m | |||||
| α7 + RIC-3 | 9.2 × 10−5 (6.9–12.5 × 10−5) | 1.2 (0.8–1.6) | 5 | 1.4 × 10−10 (0.8–2.5 × 10−10) | 1.3 (0.6–2.0) | 8 |
| α7(L9'T) | 1.3 × 10−6 (1.1–1.5 × 10−6) | 2.1 (1.5–2.6) | 5 | 1.5 × 10−10 (0.8–3.0 × 10−10) | 1.2 (0.6–1.9) | 6 |
| α4β2 (1:1) | 1.5 × 10−4 (1.1–1.9 × 10−4) | 0.91 (0.75–1.1) | 16 | 2.0 × 10−7 (1.1–3.5 × 10−7) | 1.2 (0.6–1.9) | 6 |
| α4β2 (1:10) | 1.7 × 10−6 (1.2–2.4 × 10−6) | 0.88 (0.6–1.2) | 4 | 1.3 × 10−7 (0.5–3.7 × 10−7) | 0.8 (0.4–1.2) | 3 |
| α4(D204C)β2 (1:1) | 2.6 × 10−5 (1.4–5 × 10−5) | 0.53 (0.36–0.7) | 9 | 2.7 × 10−8 (1.5–5.1 × 10−8) | 0.5 (0.3–0.6) | 7 |
| α4(D204C)β2 (1:10) | 1.9 × 10−6 (1.5–2.3 × 10−6) | 0.97 (0.8–1.1) | 6 | 1.2 × 10−7 (1.1–1.4 × 10−7) | 1.0 (0.9–1.2) | 5 |