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. 2013 Jul 24;288(37):26594–26605. doi: 10.1074/jbc.M113.472977

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — DNA constructs used in the study. A, retrovirus rv3315 encodes SV40 large T antigen driven by murine embryonic stem cell virus long terminal repeat (LTR) promoter. No antibiotic resistance marker is present. B, plasmid pMA2941 encodes CMV promoter-driven Myc-tagged cre recombinase gene. C, retrovirus rv3441 encodes Moloney murine leukemia virus LTR promoter-driven mitochondrially targeted LIG3. The gene's native MTS and an initiating codon were removed and replaced with MTS from human ornithine transcarbamylase followed by a Myc tag. D, retrovirus rv3491 encodes LTR promoter-driven cre recombinase whose expression is transcriptionally linked (through an internal ribosome entry site, IRES EMV) to the expression of the G418 resistance gene. E, lentivirus lv3380 encodes doxycycline-inducible promoter (TET)-driven mitochondrially targeted LIG3 as in C.