FIGURE 4.

Structurally characterized lysozyme inhibitors display distinct folds but act via a common mechanism. Comparison of the Tge2^PP·Tgi2^PP complex to vertebrate lysozymes in complex with proteinaceous bacterial lysozyme inhibitors. Shown are the Tge2^PP·Tgi2^PP complex (A), E. coli periplasmic lysozyme inhibitor of G-type lysozyme (PliG^EC) in complex with salmon G-type lysozyme (SalG) (B), E. coli proteinaceous inhibitor of vertebrate lysozyme (Ivy^EC) in complex with hen egg white lysozyme (HEWL) (C), and membrane-bound lysozyme inhibitor of C-type lysozyme (MliC) in complex with hen egg white lysozyme (D) (45–47). For each structural model, the lysozyme-like protein and its associated inhibitor are shown as surface and ribbon representations, respectively.