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Increased PP2Ac levels induce H3 acetylation in the Il17 locus in a constitutive manner. A and B, naïve CD4 T cells were stimulated in serum-free medium in the absence or presence of TGF-β and IL-6. After 18 h, the promoter regions of the Rorc and Il17a genes were analyzed by ChIP assays using anti-H3 acetylated or anti-H3K4me3 antibodies. Results were normalized against the input and are expressed as fold change over the WT stimulated in culture medium alone.
