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PP2Ac promotes IL-17 production by facilitating IRF4 activity. Increased levels of PP2Ac promote Rho kinase (ROCK) activation. Activated ROCK phosphorylates IRF4, which then localizes to the Il17 locus. There, IRF4 recruits histone acetyltransferases (HAT), as well as other transcription factors (TF) and RNA polymerase (RNA pol) to initiate transcription of Il17.
