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. 2013 Jul 23;288(37):26888–26897. doi: 10.1074/jbc.M113.452458

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Secretion of exosomes is inhibited by expression of DN-Rab11-GFP in Panc02 cells and altered the pancreatic cancer-discriminatory biomarker profile in mice saliva. DN-Rab11-GFP expression significantly inhibited AchE activity from the exosomes isolated from Panc02 cells when compared with Panc02 cells that are untransfected or expressing only GFP (A). Orthotopic injections of Panc02 cells developing tumors that are expressing either GFP or DN-Rab11-GFP altered the previously established salivary transcriptomic profile discriminatory for pancreatic cancer (B). Five out of the seven salivary biomarkers discriminatory for pancreatic cancer (Apbb1ip, Aspn, Incenp, Daf2, and Foxp1) were significantly up-regulated in the saliva of mice bearing GFP-expressing tumors in comparison with control. Only one out of the seven pancreatic cancer-specific salivary biomarkers (Apbb1ip) was still significantly up-regulated in the saliva of mice bearing DN-Rab11-GFP-expressing tumors in comparison with control.