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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Science. 2007 Apr 26;316(5829):1336–1341. doi: 10.1126/science.1142364

Figure 1. Overview of CDKAL1 signal region.

Figure 1

A Plot of −log(p values) for T2D (Cochran-Armitage test for trend) against chromosome position in Mb. Blue diamonds represent primary scan results and pink triangles denote meta-analysis results across all UK samples.

B Genomic location of genes showing intron and exon structure (NCBI Build 35). Pink triangles show position of replication SNPs relative to gene structure.

C MULTIZ (24) vertebrate alignment of 17 species showing evolutionary conservation.

D GoldSurfer2 (25) plot of linkage disequilibrium (r2) for SNPs genotyped in WTCCC scan (passing T2D-specific quality control) in WTCCC T2D cases.

E Recombination rate given as cM/MB. Red boxes represent recombination hotspots (26).

F GoldSurfer2 plot of linkage disequilibrium (r2) for all HapMap SNPs across the region (HapMap CEU data).