Table 1.
| Glycans | GBPs | Lectin Name or antibody Clones | Lectin Specificities or Glycan Structures |
|---|---|---|---|
| Fucose (Fuc) | AAL | Aleuria Aurantia Lectin | Fuc (preferably (α1–6) linked Fuc) |
| LCA | Lens Culinaris Agglutinin | (α1–6) linked Fuc | |
| PSA | Pisum Sativum Agglutinin | (α1–6) linked Fuc | |
| UEA I | Ulex Europaeus Agglutinin I | Terminal or subterminal Fuc (α1–2) Gal | |
| LTL | Lotus Tetragonolobus Lectin | Fuc (α1–2) Gal (β1–4)[Fuc α1–3]Glc/GlcNAc), other difucosyl carbohydrates | |
| AAA | Anguilla Anguilla Agglutinin | Fuc (α1–3) GlcNAc | |
| α linked galactose (αGal) | antibody | 2.10G, Gal-13, M86 | Gal(α1–3)Gal(β 1–4)GlcNAc-R |
| GS IB4 | GSL I -isolectin B4 | Terminal aGal | |
| MOA | Marasmius oreades agglutinin | Gal (α1–3)Gal(β1–4) GlcNAc/Glc | |
| α linked N-acetyl galactosamine (αGalNAc) (including Tn antigen (GalNAc α1 – Ser/Thr)) | antibody | B1.1, 5F4, 83D4, BRIC 111, Ca3256, Ca3268, Ca3638, CU-1, ETn1.01, FBT3, HBTn1, IE3, MLS128, NCC-LU-35, NCC-LU-81, Tn5, | GalNAc α-Thr/Ser (Tn antigen) |
| HPA | Helix pomatia agglutinin | Terminal αGalNAc | |
| HAA | Helix aspersa agglutinin | α/βGalNAc | |
| VVL | Vicia Villosa Lectin | α/βGalNAc | |
| DBA | Dolichos Biflorus Agglutinin | GalNAc (α1–3) GalNAc | |
| LBL | Lima Bean Lectin (Phaseolus lunatus) | GalNAc (α1–3) Gal | |
| MPL | Maclura Pomifera Lectin | αGalNAc | |
| SBA | Soybean Agglutinin | αGalNAc | |
| WFA | Wisteria Floribunda Lectin | GalNAc (α/β1–6/3) Gal | |
| β linked galactose (βGal) | PNA | Peanut Agglutinin | Terminal βGal |
| RCA120 | Ricinus Communis Agglutinin I | Terminal βGal as in Lactose/LacNAc | |
| ABA | Agaricus bisporus agglutinin | βGal on T antigen | |
| ACA | Amaranthus Caudatus Lectin | βGal on T antigen | |
| β linked N-acetyl galactosamine (βGalNAc) | SJA | Sophora Japonica Agglutinin | βGal and βGalNAc |
| PTL II | Psophocarpus Tetragonolobus Lectin II | βGal and βGalNAc | |
| SBA | Soybean Agglutinin | βGalNAc and αGalNAc | |
| WFA | Wisteria Floribunda Lectin | GalNAc (α/β1–6) Gal and GalNAc (α/β1–3) Gal | |
| GalNAc(β1–3)Gal(β1–4)GlcNAc | antibody | TH2 | GalNAc(β1–3)Gal(β1–4)GlcNAc-R |
| GalNAc(β1–4)[Fuc(α1–3)]Glc(β1−) | antibody | AK97 | Gal(β1–4)[Fuc(α1–3)]Glc(β1−)-R |
| GalNAc(β1–4)[Neu5Ac(α2–3)]Gal(β1−) | antibody | 2A3D2, 2D11E2, CT1, CT2, DMAb-1, DMAb-2, DMAb-3, DMAb-4, DMAb-5, KM531, YHD-06 | GalNAc(β1–4)[Neu5Ac(α2–3)]Gal(β1−)-R |
| GalNAc(β1–4)Gal | antibody | 2D4 | GalNAc(β1–4)Gal-R |
| T antigen (Gal-β1–3 GalNAc α1-Ser/Thr) | antibody | 49H.24, 49H.8, 5A8, 8D8, A78-G, Ca3114, Ca3741, HB-T1, HH8, TF1, TF2, TF5 | Gal (β1–3) GalNAc a-Thr/Ser (T antigen) |
| BPL | Bauhinia Purpurea Lectin | Gal (β1–3) GalNAc or terminal αGalNAc | |
| PNA | Peanut Agglutinin | terminal Gal (β1–3) GalNAc a-Thr/Ser (T antigen), terminal βGal | |
| Jacalin | Jacalin | Gal (β1–3) GalNAc α-Thr/Ser,GalNAc α-Thr/Ser(Tn) | |
| VVL | Vicia Villosa Lectin | Terminal Gal β1–3 GalNAc α-Thr/Ser or terminal αGalNAc α-Thr/Ser | |
| Sialyl T antigen | antibody | Neu5Ac (α2–3)Gal(β1,3)GalNAc] α-Ser/Thr | |
| Disialyl T antigen | antibody | QSH2 | Neu5Ac(α2–3)Gal(β1–3)[Neu5Ac(α2–6)]GalNAc(α1−)Ser/Thr |
| Terminal Galactose 3-O-Sulfate | antibody | M14–376, Sulph 1 | HSO3(−3)Gal-R |
| Sialyl Tn antigen | antibody | B72.3, C1282, CC102, CC49, HB-STn1, 3C2, MLS132, | Neu5Ac (α2–3) GalNAc](α−)-Ser/Thr |
| Glucose (Glc) | VFA | Vicia faba agglutinin | α–linked Glc and α–linked Man |
| Con A | Concanavalin A | α–linked Glc and α–linked Man | |
| N-acetyl-Glucose (GlcNAc) | GSL II | Griffonia (βandeiraea) Simplicifolia Lectin II | Terminal βGlcNAc or αGlcNAc |
| PVL | Psathyrella velutina lectin | βGlcNAc | |
| O-linked GlcNAc (O-GlcNAc) | antibody | CTD110.6, HGAC39, HGAC85, RL2 | GlcNAc(β1−)Ser/Thr |
| Chitobiose (GlcNAc (β1–4)GlcNAc) | WGA | Wheat Germ Agglutinin | (GlcNAc (β1–4) GlcNAc)n repeats |
| DSL | Datura Stramonium Lectin | GlcNAc oligomer | |
| LEL | Lycopersicon Esculentum (Tomato) Lectin | GlcNAc oligomer | |
| STL | Solanum Tuberosum (Potato) Lectin | GlcNAc oligomer | |
| UDA | Urtica dioica agglutinin | GlcNAc oligomer | |
| LacNAc (Gal (β1–4) GlcNAc) | antibody | 1B2 (to Terminal LacNAc) | Terminal LacNAc |
| ECL | Erythrina Cristagalli Lectin (ECL, ECA) | Terminal LacNAc | |
| RCA120 | Ricinus Communis Agglutinin I | LacNAc (binding inhibited by terminal sialic acid) | |
| Branched (β1–6) LacNAc | PWM | Pokeweed mitogen lectin | Gal (β1–4) GlcNAc (β1–6) -R |
| L-PHA | Phaseolus vulgaris Leucoagglutinin | Gal (β1–4) GlcNAc (β1–6) -R | |
| 6-Sulfo LacNAc | antibody | AG107, DD1, DD2, M-DC8 | Gal(β1–4)[HSO3(−6)]GlcNAc -R |
| 6,6'-Sulfo LacNAc | antibody | DD1, M-DC8 | HSO3(−6)Gal(β1–4)[HSO3(−6)]GlcNAc(β1−)-R |
| 6,6,6'-Sulfo LacNAc | antibody | DD1 | HSO3(−6)Gal(β1–4)[HSO3(−6)]GlcNAc(β1–3)[HSO3(−6)]Gal(β1−)-R |
| LDN (LacdiNAc) | antibody | 100-2H5-A, 114-2H12-C, 259-2A1, 273-3F2, 99-2A5-B, SMLDN1.1, | GalNAc(β1–4)GlcNAc-R |
| LDN-F | antibody | 204-6A1, 294-2A1, SMLDNF1 | GalNAc(β1–4)[Fuc(α1–3)]GlcNAc-R |
| Acharan Sulfate | antibody | MW3G3 | -{[HSO3(−2)]IdoA(α1–4)GlcNAc(α1–4)}n− |
| Lewis a | antibody | 7LE, PR.5C5, PR 4D2, T174, B369, BC9-E5, CF4-C4 DG4-1, | Gal(β1–3)[Fuc(α1–4)]GlcNAc(β1−)-R |
| Dimeric Lewis a | antibody | NCC-ST-421 | Gal(β1–3)[Fuc(α1–4)]GlcNAc(β1–3)Gal(β1–3)[Fuc(α1–4)] GlcNAc(β1−)-R |
| Disialyl Lewis a | antibody | FH7 | Neu5Ac(α2–3)Gal(β1–3)[Neu5Ac(α2–6)][Fuc(α1–4)] GlcNAc(β1−)-R |
| 3'-Sulfo Lewis a | antibody | F2, 91.9H, | HSO3(−3)Gal(β1–3)[Fuc(α1–4)]GlcNAc-R |
| Sialyl Lewis a (CA19-9) | antibody | 121SLE, CA199.02, 2M1, SPM110, 241, 192 | Neu5Ac (α2–6))Gal(β1–3)[Fuc(α1–4)]GlcNAc-R |
| Lewis a- Lewis x Hybrid Antigen | antibody | 43-9F, NCC-ST-421 | Gal(β1–3)[Fuc(α1–4)]GlcNAc(β1–3)Gal(β1–4)[Fuc(α1–3)] GlcNAc(β1−)-R |
| Lewis b | antibody | 2–25LE, T218, SPM194, 1116NS-10, YB-2, | Fuc(α1–2)Gal(β1–3)[Fuc(α1–4)]GlcNAc(β1−)-R |
| Trifucosyl-Lewis b Antigen | antibody | IMH2 | Fuc(α1–2)Gal(β1–3)[Fuc(α1–4)]GlcNAc(β1–3)Gal(β1–3)[Fuc(α1–4)] GlcNAc(β1−)-R |
| Lewis c | antibody | K21 | Fuc(α1–2)Gal(β1–3)[Fuc(α1–4)]GlcNAc(β1–3)Gal(β1–3)[Fuc(α1–4)] GlcNAc(β1−)-R |
| Sialyl Lewis c | antibody | C-50, DUPAN-2 | Neu5Ac(α2–3)Gal(β1–3)GlcNAc(β1−)-R |
| Lewis x | antibody | 15C02, 28, ZC-18C, FR4A5, HI98, W6D3, P12, 1G10, 73-30, 80H5, FH2, LeuM1, MC-480, MMA, SH1, WGHS-29-1 | Gal(β1–4)[Fuc(α1–3)]GlcNAc(β1−)-R |
| Sialyl Lewis x | antibody | CSLEX1 | Neu5Ac (α2–6)Gal(β1–4)[Fuc(α1–3)]GlcNAc–R |
| Dimeric Lewis x | antibody | FH4 | Gal(β1–4)[Fuc(α1–3)]GlcNAc(β1–3)Gal(β1–4)[Fuc(α1–3)] GlcNAc(β1−)-R |
| 3'-Sulfo Lewis x | antibody | MIN/3/60, SU59 | HSO3(−3)Gal(β1–4)[Fuc(α1–3)]GlcNAc-R |
| 6-Sulfo Lewis x | antibody | AG107, AG273, AG97 | Gal(β1–4)[Fuc(α1–3)][HSO3(−6)]GlcNAc(β1−)-R |
| Sialyl 6-Sulfo Lewis x | antibody | 2F3, 2H5, G162, G72, HECA-452, | Neu5Ac(α2–3)Gal(β1–4)[Fuc(α1–3)][HSO3(−6)] GlcNAc(β1−)-R |
| 6'-Sulfo Sialyl Lewis x | antibody | 2F3, 2H5, CSLEX1 / CSLEX-1, HECA-452, SNH3 / SNH-3 | Neu5Ac(α2–3)[HSO3(−6)]Gal(β1–4)[Fuc(α1–3)]GlcNAc(β1−)-R |
| 6,6'- Disulfo Sialyl Lewis x | antibody | 2F3, 2H5, G27011, G27037, G27039, G2706, HECA-452 | Neu5Ac(α2–3)[HSO3(−6)]Gal(β1–4)[Fuc(α1–3)][HSO3(−6)]GlcNAc(β1–3) Gal(β1−)-R |
| Sialyl Lewis i-x (VIM-2) | antibody | CF4, HE-10, VIM-2 | Neu5Ac(α2–3)Gal(β1–4)GlcNAc(β1–3)Gal(β1–4)[Fuc(α1–3)] GlcNAc(β1−)-R |
| Sialyl Lewis x-i | antibody | FH6 | Neu5Ac(α2–3)Gal(β1–4)[Fuc(α1–3)]GlcNAc(β1–3)Gal(β1–4) GlcNAc(β1–3)Gal(β1−)-R |
| Cyclic Sialyl 6-Sulfo Lewis x | antibody | G159 | Cyclic Neu5Ac (α2–3) Gal(β1–4)[Fuc(α1–3)[HSO3(−6)]GlcNAc-R |
| Lewis y | antibody | BR55, F3, A70-C/C8, A63-D/B12, 3S193, AH6, BR96, H18A, YB-2, | Fuc(α1–2)Gal(β1–4)[Fuc(α1–3)]GlcNAc-(β1−)-R |
| Trifucosyl-Lewis y | antibody | KH1 | Fuc(α1–2)Gal(β1–4)[Fuc(α1–3)]GlcNAc(β1–3)Gal(β1–4)[Fuc(α1–3)] GlcNAc(β1−)-R |
| Mannose (Man) | Con A | Concanavalin A | Terminal α-Man, branched tri-Man |
| LCA | Lens Culinaris Agglutinin | Terminal α-Man | |
| GNL | Galanthus Nivalis Lectin | Terminal Man (α1–2)Man, Mana(α1–6) Man | |
| BanLec | Banana Lectin (Musa Acuminata) | a-Man, 3-O-a-Man, branched tri-Man | |
| O-Mannosyl Glycan (Mammalian) | antibody | IIH6 | Neu5Ac(α2–3)Gal(β1–4)GlcNAc(β1–2)Man(α1−)Ser/Thr |
| Sialic acid (Neu5Ac) | SNA | Sambucus Nigra Lectin | α2–6 linked Neu5Ac |
| MAL II | Maackia Amurensis Lectin II | Neu5Ac (α2–3) Gal | |
| SSA | S. sieboldiana agglutinin | NeuAc(α2–6)Gal/GalNAc | |
| TJA-I | Trichosanthes japonica agglutinin I | NeuA(α2–6)Gal | |
| PSL | Polyporus squamosus lectin | Neu5Ac (α2–6)Gal(β1–4)GlcNAc/Glc | |
| LPA | Limulus polyphemus agglutinin | Neu5Ac | |
| LFA | Limax flavus agglutinin | Neu5Ac | |
| 9-O-Acetyl Sialic Acid | antibody | 493D4, CH#-FcD, | Neu5Ac9Ac(α2−)-R |
| Poly-N-Acetylneuraminic Acid | antibody | 12E3, 1E6, 2-2B, 5A5, 735, H.46, OL28, S2–566 | (Neu5Ac) n |
| KDN-Gal (KDN: 3-deoxy-D-glycero-D-galacto-nonulosonic acid) | antibody | Kdn3G | KDN(α2–3)Gal(β1−)-R |
| Poly-KDN | antibody | Kdn8kdn | (KDN)n |
| Neu5Ac(α2–3)Gal (Monosialoganglioside) | antibody | 202 | Neu5Ac(α2–3)Gal-R |
| Neu5Ac(α2–3)Gal(β1) | antibody | FCM1, | Neu5Ac(α2–3)Gal(β1−)-R |
| Neu5Ac(α2–3)Gal(β1–4)Glc | antibody | M2590, MSG-1, | Neu5Ac(α2–3)Gal(β1–4)Glc-R |
| Neu5Ac(α2–3)Gal(β1–4)GlcNAc | antibody | M2590, NS24, SPS-20 | Neu5Ac(α2–3)Gal(β1–4)GlcNAc-R |
| Neu5Ac(α2–8)Neu5Ac(α2–3)Gal | antibody | A1–245, A1–267, HJM1, R24 | Neu5Ac(α2–8)Neu5Ac(α2–3)Gal-R |
| Neu5Ac(α2–8)Neu5Ac(α2–3)Gal(β1–4)Glc | antibody | DMAb-19, DMAb-7, DMAb-8, DSG-1, GMB7 | Neu5Ac(α2–8)Neu5Ac(α2–3)Gal(β1–4)Glc-R |
| Blood Group A Trisaccharide | antibody | 3–3a, AC1001, AC12, B2C114, CB, HB29–36, K7422, K7522, K7516, S10-11A6, | GalNAc(α1–3)[Fuc(α1–2)]Gal(β1−)-R |
| Blood Group A Type 1 | antibody | AH16, AH21, CB, CLH6, HB29–36, T36 | GalNAc(α1–3)[Fuc(α1–2)]Gal(β1–3)GlcNAc(β1−)-R |
| Blood Group A Type 2 | antibody | 11D4, 3A7, AH16, CB, HB29–36, T36 | GalNAc(α1–3)[Fuc(α1–2)]Gal(β1–4)GlcNAc(β1−)-R |
| Blood Group A Type 3 | antibody | CB, HB29–36, K45aF3, M2, MRG-1 | GalNAc(α1–3)[Fuc(α1–2)]Gal(β1–3)GalNAc(α1−)-R |
| Blood Group A Type 4 | antibody | CB, HB29–36, M2, | GalNAc(α1–3)[Fuc(α1–2)]Gal(β1–3)GalNAc(β1−)-R |
| Blood Group B Type 2 | antibody | 3A7, CLCP-19B, | Gal(α1–3)[Fuc(α1–2)]Gal(β1–4)GlcNAc(β1−)-R |
| Blood Group H Disaccharide | antibody | 1E3, 3H1, B389 | Fuc(α1–2)Gal(β1−)-R |
| Blood Group H Type 1 | antibody | 0.BG.5, 17–206, 1E3, 1E5, 3H1, BE2, H1B4 | Fuc(α1–2)Gal(α1–3)GlcNAc(β1−)-R |
| Blood Group H Type 2 | antibody | 0.BG.5, 1E3, 1E5, 3A5, 3H1, 92 FR A2, B376, B389, B393, BE2, BRIC231, H1B4, YB02 | Fuc(α1–2)Gal(β1–4)GlcNAc(β1−)-R |
| Blood Group H Type 3 | antibody | 1E3, 3H1, MBr1 | Fuc(α1–2)Gal(β1–3)GalNAc(α1−)-R |
| Blood Group H Type 4 | antibody | 1E3, 3H1, MBr1 | Fuc(α1–2)Gal(β1–3)GalNAc(β1−)-R |
| SSEA-1 | antibody | SSEA-1 | Gal(β1–4)[Fuc(α1–3)]GlcNAc(β1–3)Gal(β1–4)GlcNAc (β1–3)Gal(β1−)-R |
| SSEA-3 | antibody | MC631, SSEA-3 | Gal(β1–3)GalNAc(β1–3)Gal(α1−)-R |
| SSEA-4 | antibody | MC813-70 | Neu5Ac(α2–3)Gal(β1–3)GalNAc(β1–3)Gal(α1−)-R |
| Heparan Sulfate | antibody | 10E4, AO4B08, HepSS1, HK249, HS3A8, HS3B7, HS4C3, HS4E4, J403, JM13, MW3G3, NAH46, RB4EA12, | -[{[±(HSO3(-2))GlcA(β1–4)]or[±(HSO3(−2))IdoA(α1–4)]} (±(HSO3(−3)) ±[(HSO3 or CH3CO)(−2)]±(HSO3(−6))GlcN]n− |
| Delta-Heparan Sulfate | antibody | 3G10 | unsaturated HexA-R |
| Keratan Sulfate | antibody | 5D4 | -{HSO3(−6)GlcNAc(β1–3)±[HSO3(−6)]Gal(β1–4)}n− |
| P1 Antigen | antibody | P001, Pk002 | Gal(α1–4)Gal(β 1–4)GlcNAc-R |
| Pk Antigen | antibody | 38.13, P001, Pk002, PK67 | Gal(α1–4)Gal(β 1–4)Glc-R |
| HNK-1 | antibody | 334, 4F4, Elec39, HNK-1, L2, M6749, NC-1, NGR50, NSP-4, VC1.1, | HSO3(−3)GlcA(β1–3)Gal(β1–4)GlcNAc-R |
| I-Antigen | antibody | Anti-I Ma, anti-I Woj, C6 | Gal(β 1–4)GlcNAc(β 1–6)[Gal(β 1–4)GlcNAc(β 1–3)]Gal(β 1–4)GlcNAc(β 1−)-R |