Table 1. Area under ROC curve between normal controls and eyes with RNFL defects.
| Normal eyes (n=72) | Eyes with localized RNFL defects (n=64) | P-value | AUCs (95% CI) | Sensitivity/specificity (Sp≥80%) | Sensitivity/specificity (Sp≥90%) | |
|---|---|---|---|---|---|---|
| CpRNFL thickness (μm) | ||||||
| Average | 104.2±8.9 | 84.0±13.9 | <0.001 | 0.890 (0.836–0.944) | 75/81 | 72/90 |
| Quadrant | ||||||
| Temporal | 80.2±11.8 | 69.8±12.2 | <0.001 | 0.726 (0.641–0.811) | 55/81 | 42/90 |
| Superior | 123.9±12.0 | 101.8±19.4 | <0.001 | 0.840 (0.772–0.908) | 78/82 | 63/90 |
| Nasal | 84.6±14.8 | 74.1±15.8 | <0.001 | 0.694 (0.605–0.783) | 48/82 | 28/92 |
| Inferior | 128.1±11.8 | 90.6±23.4 | <0.001 | 0.910 (0.861–0.959) | 83/82 | 78/90 |
| Clock-hour | ||||||
| 9 | 69.4±17.4 | 64.5±12.6 | 0.06 | 0.597 (0.500–0.693) | 34/81 | 23/90 |
| 10 | 92.3±13.7 | 78.1±19.0 | <0.001 | 0.724 (0.637–0.811) | 55/81 | 45/90 |
| 11 | 128.8±19.6 | 100.1±29.3 | <0.001 | 0.784 (0.705–0.862) | 63/81 | 55/90 |
| 12 | 121.4±19.3 | 102.7±23.7 | <0.001 | 0.757 (0.676–0.838) | 52/81 | 39/90 |
| 1 | 121.4±15.0 | 102.9±21.2 | <0.001 | 0.761 (0.682–0.841) | 58/83 | 44/90 |
| 2 | 99.5±17.1 | 84.2±20.0 | <0.001 | 0.724 (0.638–0.810) | 53/81 | 33/90 |
| 3 | 74.0±16.3 | 66.4±15.6 | 0.006 | 0.646 (0.552–0.739) | 36/82 | 19/92 |
| 4 | 79.9±18.4 | 71.6±19.4 | 0.01 | 0.633 (0.539–0.727) | 36/80 | 20/90 |
| 5 | 111.7±17.9 | 96.1±21.3 | <0.001 | 0.721 (0.635–0.808) | 52/82 | 38/90 |
| 6 | 133.5±19.2 | 94.5±27.8 | <0.001 | 0.865 (0.803–0.928) | 77/81 | 72/90 |
| 7 | 138.8±17.4 | 81.1±35.6 | <0.001 | 0.898 (0.840–0.956) | 83/86 | 81/94 |
| 8 | 78.9±12.4 | 66.8±15.4 | <0.001 | 0.746 (0.662–0.831) | 64/81 | 41/92 |
| Macular inner retina thickness (μm) | ||||||
| NFL | ||||||
| Superior | 33.9±5.0 | 29.3±7.1 | <0.001 | 0.720 (0.631–0.810) | 58/81 | 42/90 |
| Inferior | 37.3±4.7 | 23.5±10.7 | <0.001 | 0.855 (0.782–0.928) | 77/82 | 75/92 |
| Total | 35.5±4.4 | 26.4±7.5 | <0.001 | 0.848 (0.774–0.921) | 80/82 | 75/93 |
| GCL+IPL | ||||||
| Superior | 71.4±6.0 | 65.5±5.6 | <0.001 | 0.775 (0.697–0.853) | 53/81 | 41/92 |
| Inferior | 70.1±5.9 | 60.0±6.3 | <0.001 | 0.889 (0.833–0.945) | 77/83 | 69/96 |
| Total | 70.8±5.1 | 62.8±5.1 | <0.001 | 0.869 (0.810–0.928) | 67/82 | 61/90 |
| GCC | ||||||
| Superior | 105.4±8.8 | 94.8±11.6 | <0.001 | 0.771 (0.690–0.851) | 59/81 | 41/90 |
| Inferior | 107.3±8.6 | 83.5±15.9 | <0.001 | 0.888 (0.830–0.946) | 80/82 | 73/90 |
| Total | 106.4±8.5 | 89.2±11.9 | <0.001 | 0.872 (0.811–0.933) | 77/82 | 70/92 |
| Normal eyes (n=72) | Eyes with localized RNFL defects (n=64) | P-value | AUCs (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|---|---|---|---|
| Angular width of RNFL defects (degree) | ||||||
| Photography | 0 | 32.4±21.1 | <0.001 | 1.0 (0.972–1.000) | 100 (94.4–100) | 100 (94.9–100) |
| Thickness map | 0.33±1.91 | 29.4±21.6 | <0.001 | 0.985 (0.946–0.998) | 98.4 (91.5–100) | 97.0 (89.6–99.6) |
| Significance map | 0.86±4.05 | 43.9±30.7 | <0.001 | 0.983 (0.938–0.997) | 98.2 (90.4–100) | 95.5 (87.5–99.1) |
| Area of RNFL defects (mm2) | ||||||
| Photography | 0 | 2.46±1.50 | <0.001 | 1.0 (0.973–1.000) | 100 (94.4–100) | 100 (95.0–100) |
| Thickness map | 0.01±0.04 | 2.04±1.33 | <0.001 | 0.992 (0.958–1.000) | 98.4 (91.6–100) | 98.6 (92.5–100) |
| Significance map | 0.05±0.28 | 2.68±1.76 | <0.001 | 0.975 (0.932–0.994) | 96.9 (89.2–99.6) | 95.8 (88.1–99.1) |
Abbreviations: AUC, area under the receiver operating characteristic curve; CI, confidence interval; GCC, ganglion cell complex;GCL, ganglion cell layer; IPL, inner plexiform layer; NFL, nerve fiber layer; RNFL, retinal nerve fiber layer; ROC, receiver operating characteristic; Sp, specificity.