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. 2013 Sep 15;126(18):4069–4076. doi: 10.1242/jcs.096024

Fig. 4.

Fig. 4.

Non-random sister chromatid segregation of X and Y chromosomes during GSC division. (A) Sister chromatid segregation pattern of X and Y chromosomes examined by CO-FISH. GSCs inherit the red (Cy3-based) signal in a majority of the cases, suggesting that GSCs inherit particular sister chromatids of X and Y chromosomes with a striking bias (85%∶15%) (compare with Fig. 2B). (B) Sister chromatid segregation pattern of the autosomes observed in GSCs. GSCs inherit two Cy3 signals or two Cy5 signals with equal probability, but never a Cy3 and a Cy5 signal, suggesting the existence of a certain type of bias (compare with Fig. 2B). The CO-FISH experiments using the chromosome II probe and chromosome III probe showed the same trend. (C) Model of non-random sister chromatid segregation of X and Y chromosomes. Sister chromatids might be distinctly recognized by the SUN–KASH components of the LINC complex, resulting in the anchorage of particular DNA strands to the mother centrosome that is mediated by microtubule–LINC interactions (see text for further details). Adaptor protein(s) might link SUN–KASH proteins and the sister chromatid.