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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Integr Biol (Camb). 2011 Nov 17;4(4):440–448. doi: 10.1039/c1ib00090j

Figure 1. Morphologies of lung cancer cell lines grown in 3D.

Figure 1

A. Lung cancer cells adopt a flattened morphology when grown on tissue culture plastic (2D, top row), but can form smooth, round masses (H1437, H358, H2170, and A549), grape-like structures (ChagoK1), or invasive, branching structures (H23 and H1703) when grown in 3D lrECM cultures (3D, bottom row). Scale bar 50 mm. B. Expression of actin cytoskeleton (Actin, top row), E-cadherin (second row), cell nuclei (Hoechst, third row), and all three stains merged (Actin red, E-cadherin green, Hoecht blue; bottom row) of lung cancer cells grown in 3D. Scale bar 20 μm.