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Cyclization of the Ugi 4-CR to yield the pyrrolidinedione scaffold
| Comp. | R1–NC |
|
|
|
Yielda [%] |
|---|---|---|---|---|---|
| 9a |
|
|
|
|
40 |
| 9b |
|
|
|
|
49 |
| 9c |
|
|
|
|
45 |
| 9d |
|
|
|
|
34 |
Overall yield in two steps in one pot (crude Ugi product was directly used for the cyclization).
