Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Cyclization of the Ugi 4-CR to yield to yield bicyclic tetrahydroimidazo[1,2-a]pyrazine-2,6(3H,5H)-dione scaffold
| Comp. | R1–NC |
|
Yielda [%] |
|---|---|---|---|
| 13a |
|
|
63 |
| 13b |
|
|
87 |
| 13c |
|
|
40 |
| 13d |
|
|
54 |
Overall yield in two steps in one pot (crude Ugi product was directly used for the cyclization).
