Table II.
Demographic Differences Between Diagnostic Cohorts
| Depressed (N = 54) | Nondepressed (N = 37) | Test value | P | |
|---|---|---|---|---|
| Age (yr) | 68.9 (5.6) | 73.8 (5.8) | t = 4.25 | 0.0001 |
| Sex, % Female (N) | 64.8 (35) | 64.9 (24) | χ2 = 0.00 | 0.9961 |
| Race, % Caucasian (N) | 83.3 (45) | 94.6 (35) | Fisher's exact | 0.1888 |
| MMSE | 28.9 (1.3) | 29.2 (0.9) | t = 0.89 | 0.3785 |
| MADRS | 10.1 (7.8) | — | — | — |
| Cerebral WML volume (ml) | 8.7 (9.3) | 8.8 (12.7) | t = 0.06 | 0.9497 |
| Total cerebral volume (ml) | 1,238.1 (145.6) | 1,259.5 (126.1) | t = 0.73 | 0.4690 |
| Cerebral WML ratio | 0.0070 (0.0072) | 0.0068 (0.0090) | t = 0.10 | 0.9200 |
| Genetic cohort | N = 29 | N = 33 | ||
| AGTR1 genotype | ||||
| A/A | 58.6% (17) | 57.6% (19) | χ2 = 0.01 | 0.9337 |
| C allele carrier | 41.4% (12) | 42.4% (14) | ||
| BDNF genotype | ||||
| Val/Val | 58.6% (17) | 72.7% (24) | χ2 = 1.37 | 0.2416 |
| Met allele carrier | 41.4% (12) | 27.3% (9) | ||
All continuous variables presented as mean (standard deviation) and were compared using pooled, two‐tailed t‐tests with 89 degrees of freedom. Categorical variables presented as percentage (N) and compared using a χ2 test (for sex, AGTR1, and BDNF) or Fisher's exact test (for race), with 1 degree of freedom.
MADRS = Montgomery Asberg Depression Rating Scale; MMSE = Mini‐mental state exam; WML = white matter lesion.