Table IV.
Differences in Fiber Tract WML (ftWML) Ratios by AGTR1 A1166C Genotype
| Cohort | ATR, L | ATR, R | CCF | CCO | CgH, L | CgH, R | CgC, L | CgC, R | CST, L | CST, R |
|---|---|---|---|---|---|---|---|---|---|---|
| AGTR1 aa (N = 36) | 0.0084 (0.0126) | 0.0085 (0.0081) | 0.0030 (0.0056) | 0.0094 (0.0092) | 0.0007 (0.0012) | 0.0037 (0.0049) | 0.0006 (0.0015) | 0.0005 (0.0010) | 0.0036 (0.0049) | 0.0041 (0.0066) |
| AGTR1 c/* (N = 26) | 0.0205 (0.0277) | 0.0240 (0.0328) | 0.0075 (0.0128) | 0.0199 (0.0250) | 0.0009 (0.0016) | 0.0045 (0.0057) | 0.0016 (0.0051) | 0.0030 (0.0056) | 0.0125 (0.0307) | 0.0159 (0.0281) |
| F (1,55) value | 4.82 | 6.37 | 3.28 | 5.39 | 0.26 | 0.72 | 0.89 | 7.26 | 2.51 | 4.94 |
| P | 0.0323 | 0.0145 | 0.0755 | 0.0240 | 0.6116 | 0.4006 | 0.3492 | 0.0093 | 0.1191 | 0.0303 |
| IFO, L | IFO, R | ILF, L | ILF, R | SLFb, L | SLFb, R | SLFt, L | SLFt, R | UNC, L | UNC, R | |
| AGTR1 aa (N = 36) | 0.0043 (0.0043) | 0.0069 (0.0076) | 0.0049 (0.0054) | 0.0063 (0.0071) | 0.0024 (0.0058) | 0.0026 (0.0055) | 0.0025 (0.0069) | 0.0027 (0.0077) | 0.0016 (0.0027) | 0.0041 (0.0044) |
| AGTR1 c/* (N = 26) | 0.0123 (0.0161) | 0.0164 (0.0215) | 0.0141 (0.0195) | 0.0091 (0.0109) | 0.0115 (0.0256) | 0.0123 (0.0252) | 0.0122 (0.0285) | 0.0115 (0.0294) | 0.0037 (0.0073) | 0.0068 (0.0069) |
| F (1,55) value | 7.75 | 5.27 | 7.31 | 1.87 | 3.73 | 4.43 | 3.39 | 2.78 | 1.60 | 2.00 |
| P | 0.0073 | 0.0256 | 0.0091 | 0.1775 | 0.0587 | 0.0399 | 0.0712 | 0.1012 | 0.2111 | 0.1633 |
Sample limited to Caucasian subjects only. Data presented as mean ratio (standard deviation). Statistical test results derive from models predicting ftWML volume, including independent variables of AGTR1 genotype, BDNF genotype, age, sex, presence of hypertension, and diagnostic cohort. See Table I for key to tract abbreviations.