Table I.
Cynomolgus IL4RA SNPs significantly associated (P < 0.05) with BHR and eosinophil counts (post-treatment with IL4/13 antagonist compared to control).
| Cynomolgus IL4RA polymorphism | Rhesus chromosome 20 location | IL4RA SNP location | Major/minor allele; minor allele frequency | BHR P value | Eosinophil P value |
|---|---|---|---|---|---|
| PR2 | 25763581 | 5’ proximal | C/T; 0.26 | 0.03 | 0.61 |
| PR11 | Gap | 5’ proximal | C/T; 0.02 | 0.14 | 0.05 |
| PR20 | 25763996 | 5’ proximal | T/A; 0.02 | 0.14 | 0.05 |
| In1_5 | Gap | intron | G/C; 0.27 | 0.04 | 0.65 |
| In3_2 | 25794379 | Coding Syn Ser | C/T; 0.07 | 0.04 | 0.60 |
| In3_3 | 25794391 | intron | T/C; 0.08 | 0.02 | 0.44 |
| Ex5_2 | 25799301 | Coding Syn Asn | C/T; 0.26 | 0.03 | 0.61 |
| In5_7 | 25799454 | intron | C/T; 0.02 | 0.03 | 0.01 |
| In7_2 | 25803175 | intron | G/C; 0.08 | 0.64 | 0.05 |
| In8_3 | 25806353 | intron | G/A; 0.02 | 0.14 | 0.05 |
| Ex9_3 | 25809423 | Coding Syn Ile | C/T; 0.34 | 0.04 | 0.74 |
| In10_4 | 25811349 | intron | G/A; 0.33 | 0.05 | 0.91 |
| In10_5 | 25811415 | intron | C/T; 0.36 | 0.05 | 0.82 |
BHR, bronchial hyperresponsiveness