Table 4.
Relative Risk of Colorectal Cancer According to Plasma Adiponectin and Soluble Leptin Receptor by Cancer Subsite, in the Nurses’ Health Study (1990–2008) and Health Professionals Follow-up Study (1994–2008)
| Q1a
|
Q2
|
Q3
|
Q4
|
Ptrendc | Pheterogeneityd | ||||
|---|---|---|---|---|---|---|---|---|---|
| No. of Cases | No. of Cases | RR (95% CI)b | No. of Cases | RR (95% CI)b | No. of Cases | RR (95% CI)b | |||
| Adiponectin | |||||||||
| Women | 0.36 | ||||||||
| Colon cancer | 86 | 56 | 0.72 (0.47, 1.09) | 56 | 0.67 (0.44, 1.02) | 75 | 0.95 (0.63, 1.43) | 0.77 | |
| Rectal cancer | 17 | 21 | 1.31 (0.65, 2.65) | 18 | 1.18 (0.57, 2.49) | 17 | 1.26 (0.59, 2.71) | 0.59 | |
| Men | 0.95 | ||||||||
| Colon cancer | 68 | 48 | 0.72 (0.46, 1.14) | 56 | 0.89 (0.57, 1.39) | 35 | 0.60 (0.36, 0.98) | 0.08 | |
| Rectal cancer | 20 | 13 | 0.67 (0.32, 1.41) | 19 | 1.03 (0.52, 2.03) | 11 | 0.64 (0.29, 1.40) | 0.41 | |
| Soluble Leptin Receptor | |||||||||
| Women | 0.004 | ||||||||
| Colon cancer | 72 | 61 | 0.88 (0.55, 1.40) | 76 | 1.14 (0.71, 1.81) | 58 | 0.91 (0.55, 1.51) | 0.54 | |
| Rectal cancer | 12 | 11 | 1.08 (0.44, 2.66) | 26 | 3.22 (1.44, 7.21) | 24 | 3.45 (1.47, 8.07) | 0.005 | |
| Men | 0.72 | ||||||||
| Colon cancer | 67 | 53 | 0.79 (0.50, 1.25) | 50 | 0.84 (0.52, 1.34) | 37 | 0.69 (0.42, 1.16) | 0.19 | |
| Rectal cancer | 16 | 17 | 1.07 (0.51, 2.23) | 16 | 1.12 (0.53, 2.38) | 14 | 1.10 (0.50, 2.41) | 0.80 | |
Abbreviation: CI, confidence interval; Q, quartile; RR, relative risk.
Reference category (RR = 1).
Adjusted for the same variables as in model 3 in Table 3, but using polytomous logistic regression.
Tests for trend were conducted using the median values for each quartile of analyte.
Pheterogeneity for associations with colon versus rectal cancer was estimated using likelihood ratio test by comparing the polytomous logistic regression model constraining common effects for all variables on both outcomes to the model allowing the effect for analyte to vary by outcome.