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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: J Immunol. 2010 Feb 10;184(6):2847–2854. doi: 10.4049/jimmunol.0903647

FIGURE 4.

FIGURE 4

CD8 T lymphocytes exposed to adenosine have lower CD28 expression. Long-term cultures were established by stimulation with Ab-coated microbeads. DMSO, the ADA inhibitor (10 µM),oradenosine (10µM) plus ADA inhibitor (10 µM) were added on day0 and every 3 to 4 d thereafter. A, CD28 expression on CD3+CD8+ T cells in a long-term culture exposure to DMSO, ADA inhibitor (10 µM), or adenosine (10 µM) with ADA inhibitor (10µM).B,CD28messagewascomparedwithGAPDHbyQT-PCRatday70. n = 4. *p < 0.05.