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(A) Mean current-response curves showing a rightward shift in the current-response function during the estradiol withdrawal phase. Data are displayed with a sigmoid curve fit to all of the values generated during testing across animals in the experimental group (n=7). (B) Mean + SE effective current (ECu50) values. There was an elevated ECu50 during estradiol withdrawal versus estradiol administration (t=-3.2, p=.007).
