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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: J Immunol. 2013 Aug 5;191(5):2372–2383. doi: 10.4049/jimmunol.1300107

Figure 1. ADAP-deficient T cells show impaired antigen-dependent T cell activation in vivo.

Figure 1

CTV-labeled wild-type and ADAP−/− DO11.10 T cells (200,000 T cells each) were co-transferred into IFA/OVA primed hosts. (A) Proliferation in the draining LNs was assessed at different times. Proliferation (B) and PD-1 expression (D) was assessed at 48 hours post-transfer at different antigen concentrations. (C) CTV-labeled wild-type and ADAP−/− DO11.10 T cells (10,000 cells each) were co-transferred into IFA/OVA ear primed hosts. Clonal expansion in the draining LNs was assessed at the indicated times. All plots are each representative of at least 3 independent experiments. *, P<0.05 unpaired t test.