Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2014 Sep 1.

Published in final edited form as: Oral Oncol. 2013 Jul 23;49(9):893–902. doi: 10.1016/j.oraloncology.2013.06.011

(A) Panel of images represent axial T2-weighted images of mice showing subcutaneous FaDu tumors from control, VDA alone (DMXAA 25 mg/kg, i.p.), chemotherapy alone (CPT-11 50 mg/kg, i.p.) and combination groups (n=6 tumors per group). Images were acquired 48 hours post 2^nd dose of treatment. (B) Bar graph shows tumor volumes calculated from multislice T2-weighted images of animals in all four groups (*p<0.05, ***p<0.001). (C) Panel of images represents photomicrographs of hematoxylin & eosin (H&E) and Ki67 stained sections of tumors from control and treatment groups (n = 3 per group). Whole tumor sections are also shown adjacent to the 10x magnified images. Quantitative estimates of necrosis (D) and Ki67 staining (E) showed increased necrosis and decreased in tumor proliferation following combination treatment compared to controls and either monotherapy (*p<0.05, **p<0.01***p<0.001).

(A) Panel of images represent axial T2-weighted images of mice showing subcutaneous FaDu tumors from control, VDA alone (DMXAA 25 mg/kg, i.p.), chemotherapy alone (CPT-11 50 mg/kg, i.p.) and combination groups (n=6 tumors per group). Images were acquired 48 hours post 2^nd dose of treatment. (B) Bar graph shows tumor volumes calculated from multislice T2-weighted images of animals in all four groups (*p<0.05, ***p<0.001). (C) Panel of images represents photomicrographs of hematoxylin & eosin (H&E) and Ki67 stained sections of tumors from control and treatment groups (n = 3 per group). Whole tumor sections are also shown adjacent to the 10x magnified images. Quantitative estimates of necrosis (D) and Ki67 staining (E) showed increased necrosis and decreased in tumor proliferation following combination treatment compared to controls and either monotherapy (*p<0.05, **p<0.01***p<0.001).