Table 1.
Cytotoxicity of cryptocaryol analogues (MCF-7)
| Compounds | IC50 (μM)a |
|---|---|
| cryptocaryol A (9) | 8.5 ± 2.6 |
| cryptocaryol B (10) | 6.0 ± 1.6 |
| 6-epi-ent-cryptocaryol B (2) | 14.0 ± 4.5 |
| ent-cryptocaryol A (30a) | 28.0 ± 10.7 |
| hexaol (35a) | 242 ± 180 |
| hexaol acetate (35b) | 170 ± 104 |
| 2H-cryptocaryol B (36) | >500 |
| etoposide | 1.2 ± 0.6 |
a
The IC50 values were measured from 72 h treatment of MCF-7 cells in a MTT assay. All values represent the standard error of the mean value of three independent experiments with two duplicate determinations.