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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Science. 2010 Oct 29;330(6004):612–616. doi: 10.1126/science.1191078

Figure 2. RNA-directed deposition of epigenetic signals.

Figure 2

(A-C) Sequence-specific recognition models for both sRNAs (depicted) and lncRNAs. (A) Interaction of an sRNA with complementary sequences on a nascent transcriptl. (B) Interaction of an sRNA with ssDNA to form a heteroduplex. (C) Recognition of sequence motifs by sRNA in a closed dsDNA duplex. (D-E) additional recruitment models for lncRNAs. (D) A folded lncRNA recognizes a DNA sequence via complex surface-mediated interactions. (E) A lncRNA acting locally in a co-transcriptional fashion by being anchored to chromatin by RNA PII. RBP, RNA binding protein; A, hypothetical adaptor protein; CMC, chromatin-modifying complex.