Scheme 4.
Reagents and conditions: (i) Et3N, Ac2O/reflux; ii) pyridine, HC1/200°C; iii) Ac2O/pyridine; iv) NBS /benzoyl peroxide, CCl4/hv; v) K2CO3/MeOH/acetone; vi) LiHMDS/THF/−32°C, then NBS/THF/78°C; vii) BBr3/ DCM, then NaOH/H+.
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