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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Nature. 2012 Jul 26;487(7408):496–499. doi: 10.1038/nature11218

Figure 3. Ablation of the mesenchymal dermal papilla impairs initiation of hair regeneration.

Figure 3

a, Set-up for the experiment using laser-induced cell ablation of dermal papilla cells to test the requirement of the mesenchyme for hair growth. b, High-magnification optical sections of four time points of live hair follicles whose dermal papilla was ablated (approximately telogen phase). c, Low-magnification optical sections of three time points show a group of follicles in which only a few follicles had the dermal papilla ablated (yellow arrows). b, Low-magnification optical sections of three time points show two follicles of which one had the progeny partially ablated (yellow arrow). e, Quantification of the growth of hair follicles (measured as the total length of the hair follicle) with ablated dermal papilla (top) or partially ablated progeny compartments (bottom) compared to intact control follicles. Data are expressed as mean ± s.e.m. (n = 8–10, P < 0.0001). Scale bars, 50µm.