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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Nature. 2012 Jul 26;487(7408):496–499. doi: 10.1038/nature11218

Figure 4. The cellular mechanisms that participate in hair regeneration.

Figure 4

During the initial stages of hair regeneration, the stem cell progeny is the first compartment that starts to proliferate. Cell divisions are also detected within the bulge, although the number of divisions is lower than in the stem cell progeny. Divisions in the progeny compartment are oriented along the axis of hair follicle growth, whereas orientations of divisions in the bulge are more random. The hair follicle undergoes a downwards extension in which the distance between nuclei increases within the progeny but not within the stem cell compartment. The epithelial nuclei surrounding the mesenchymal dermal papilla realign and constrict around the mensenchyme. Ablation of the mesenchyme results in impaired hair follicle growth.