Table 2.
Odd ratios for total epithelial ovarian cancer and by histologic subtypes by tubal ligation, simple hysterectomy or hysterectomy with unilateral oophorectomy in the New England Case-Control study, 1984-2008.
| Tubal Ligation | Simple hysterectomy | Hysterectomy with oophorectomy | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases (N) | Minimally-Adjusteda
OR (95%CI) |
Multivariate-adjustedb
OR (95%CI) |
P for hetc | Minimally-Adjusteda
OR (95%CI) |
Multivariate-adjustedb
OR (95%CI) |
P for hetc | Minimally-Adjusteda
OR (95%CI) |
Multivariate-adjustedb
OR (95%CI) |
P for hetc | |
| 2265 | All | 0.64 (0.54,0.75) | 0.82 (0.68,0.97) | 1.07 (0.84,1.37) | 1.09 (0.83,1.42) | 0.78 (0.55,1.11) | 0.65 (0.45,0.94) | |||
| 1008 | Serous – invasive | 0.81 (0.66, 0.99) | 0.93 (0.75, 1.16) | 0.47 | 1.23 (0.92, 1.65) | 1.24 (0.91, 1.69) | 0.80 | 0.76 (0.49, 1.16) | 0.62 (0.40, 0.98) | <0.01 |
| 286 | Serous – borderline | 0.83 (0.58, 1.19) | 1.09 (0.74, 1.59) | 1.30 (0.71, 2.36) | 1.35 (0.74, 2.47) | 1.23 (0.94, 1.63) | 1.23 (0.91, 1.64) | |||
| 116 | Mucinous – invasive | 0.35 (0.17, 0.73) | 0.47 (0.22, 0.99) | 0.33 (0.08, 1.35) | 0.34 (0.08, 1.42) | 0.88 (0.27, 2.87) | 0.90 (0.27, 2.99) | |||
| 168 | Mucinous - borderline | 0.75 (0.46, 1.21) | 0.94 (0.57, 1.57) | 0.84 (0.33, 2.10) | 0.78 (0.31, 2.00) | 1.04 (0.32, 3.40) | 0.92 (0.28, 3.06) | |||
| 365 | Endometriod | 0.33 (0.22, 0.50) | 0.46 (0.30,0.71) | 0.78 (0.45, 1.36) | 0.83 (0.46,1.47) | 0.73 (0.34,1.53) | 0.63 (0.29,1.36) | |||
| 132 | Clear Cell | 0.47 (0.26,0.85) | 0.87 (0.46,1.62) | 0.54 (0.20, 1.51) | 0.87 (0.20,1.66) | 0.24 (0.03,1.74) | 0.20 (0.03,1.53) | |||
| 190 | Other | 0.65 (0.42,1.00) | 0.77 (0.49,1.22) | 1.30 (0.74, 2.28) | 1.17 (0.65,2.11) | 0.59 (0.21,1.63) | 0.47 (0.17,1.34) | |||
Model adjusted for age one year prior to enrollment (continuous), study center (MA, NH) and study phase (NECC2-5).
Model adjusted for age one year prior to enrollment (continuous), study center (MA, NH), study phase (NECC2-5), breastfeeding duration (continuous), parity (nulliparous, 1, 2, 3, 4+ live born), OC use (<3 months, 3 months to <1 year, 1 to < 3 years, 3 to <6 years, 6 to <12 years, 12+ years), BMI (<23 kg/m2, 23 to <25 kg/m2, 25 to <30 kg/m2, 30+ kg/m2), smoking status (never, former, current), age at menarche (7 to <12, 12, 13, 14, 15+ years old), postmenopausal hormone (PMH) use (never, ever estrogen, ever estrogen plus progesterone, ever other type of hormone), family history of ovarian cancer or early onset breast cancer, talc use (yes, no), and menopausal status (premenopausal, postmenopausal) and hysterectomy status (never, ever) in TL model and TL (never, ever) in hysterectomy model. Simple hysterectomy and hysterectomy with unilateral oophorectomy were modeled simultaneously.
p-heterogeneity was determined by a likelihood-ratio test comparing a polytomous logistic regression model which assumed that estimates by histologic subtype differed compared to a model which assumed estimates by histologic subtypes did not differ.