Cystometric findings in WT and mutant young male and old female mice

	Mean ± SD WT	Mean ± SD Mutant	p Value (Student's t test)
	Young male
Bladder capacity (ml)	0.24 ± 0.11	0.25 ± 0.07
Bladder compliance (ml/cm H2O)	0.02 ± 0.01	0.02 ± 0.01
Voiding frequency (No.)	9.8 ± 4.32	9.6 ± 2.07
Vol (ml):
Voided	0.2 ± 0.04	0.08 ± 0.07	<0.05
Post-void residual	0.04 ± 0.03	0.17 ± 0.03	<0.001
Pressure (cm H2O):
Baseline	29.9 ± 6.95	32.08 ± 1.46
Threshold	42.2 ± 2.49	49.66 ± 8.74
Max	58.98 ± 5.44	60.12 ± 13.58
Intermicturition	35.52 ± 4.66	37.62 ± 3.28
Spontaneous activity	5.62 ± 2.99	5.54 ± 1.94
Time to max pressure (secs)	24.18 ± 15.16	77.9 ± 29.38	<0.05
Bladder/body wt (mg/gm)	1.08 ± 0.20	1.18 ± 0.17
	Old female
Bladder capacity (ml)	0.2 ± 0.06	0.07 ± 0.01	<0.05
Bladder compliance (ml/cm H2O)	0.012 ± 0.005	0.004 ± 0.001	<0.05
Voiding frequency (No.)	10.75 ± 4.27	29.5 ± 3.79	<0.001
Vol (ml):
Voided	0.17 ± 0.06	0.02 ± 0.01	<0.05
Post-void residual	0.04 ± 0.04	0.05 ± 0
Pressure (cm H2O):
Baseline	29.85 ± 2.04	40.45 ± 6.59	<0.05
Threshold	47.28 ± 2.14	60.45 ± 13.70
Max	64.54 ± 15.72	88.28 ± 19.85
Intermicturition	35.15 ± 1.86	46.35 ± 8.34	<0.05
Spontaneous activity	5.30 ± 0.43	6.20 ± 2.21
Time to max pressure (secs)	28.36 ± 17.82	20.55 ± 14.67
Bladder/body wt (mg/gm)	0.94 ± 0.15	1.6 ± 0.44