Figure 4.
Effect of glucocorticoid manipulation on FST immobility behavior of C57BL/6 FBGRKO-T29-1 and floxed GR mice. Mice were adrenalectomized and given an acute injection of either 5 mg/kg corticosterone (ADX + Acute Cort) or vehicle (ADX + Acute Vehicle) before a 15 min test swim 24 h earlier. Sham-adrenalectomized FBGRKO-T29-1 and floxed GR mice injected with vehicle and included as controls for the effects of adrenalectomy and forebrain GR deletion. Total time immobile and latency to first immobility were scored in a 5 min swim 24h later. *, P<0.05 vs. Sham-ADX; #, P<0.05 vs. ADX + Acute Vehicle. Ns are shown within the data bars.
