Table 2.
Baseline characteristics.
| Characteristic | Randomized
|
Completers
|
||
|---|---|---|---|---|
| Atomoxetine (n=72) | Placebo (n=75) | Atomoxetine (n = 32) | Placebo (n = 48)* | |
| AISRS, mean (SD) | ||||
| Total score | 40.6 (7.8) | 40.1 (7.9) | 39.3 (7.9) | 39.8 (7.4) |
| Hyperactive/impulsive subscale | 19.0 (5.0) | 18.7 (5.2) | 18.3 (5.1) | 18.5 (4.5) |
| Inattentive subscale | 21.7 (3.9) | 21.4 (4.1) | 21.0 (4.3) | 21.3 (4.2) |
| ASRS, mean (SD) | ||||
| Total score | 48.5 (10.1) | 51.3 (9.3) | 47.3 (8.9) | 50.1 (9.2) |
| Hyperactive/impulsive subscale | 23.6 (6.1) | 24.6 (6.0) | 22.9 (6.1) | 24.0 (6.0) |
| Inattentive subscale | 24.9 (5.5) | 26.7 (5.6) | 24.5 (5.2) | 26.1 (5.5) |
| OCDS, mean (SD) | ||||
| Total score | 20.3 (8.5) | 21.9 (8.3) | 19.1 (7.3) | 21.0 (8.2) |
| Obsessive subscale | 6.6 (4.4) | 7.4 (4.1) | 6.0 (3.8) | 6.8 (4.2) |
| Compulsive subscal | 13.7 (4.9) | 14.4 (4.9) | 13.1 (4.5) | 14.1 (4.8) |
| Mean (SD) number of alcohol-free days at baseline (from Visit 1 to 2) | NA | NA | 7.3 (4.7) | 7.9 (3.8) |
| Alcohol use disorder, n (%) | ||||
| Alcohol abuse | 33 (45.8) | 32 (42.7) | 17 (53.1) | 19 (39.6) |
| Alcohol dependence | 39 (54.2) | 43 (57.3) | 15 (46.9) | 29 (60.4) |
| Drinking-related measures, mean (SD)** | ||||
| Drinks per day | 2.0 (1.5) | 2.0 (1.8) | 2.1 (1.3) | 2.6 (2.1) |
| Proportion of drinking days | 0.3 (0.2) | 0.3 (0.2) | 0.4 (0.2) | 0.4 (0.2) |
| Drinks per drinking day | 6.5 (2.9) | 6.7 (3.5) | 5.9 (2.8) | 6.2 (4.3) |
| Proportion of days using substances other than alcohol | 0.07 (0.2) | 0.04 (0.1) | 0.01 (0.0) | 0.03 (0.1) |
There were no significant between-group differences in baseline characteristics.
Baseline drinking was assessed from Visit 1 to 2 or for 3 weeks either preceding study entry or from the beginning of the current period of sobriety. Because drink numbers were tracked using the timeline followback method, drinking records at Visit 2 comprised the drinking baseline, N values are for study participants completing 12 weeks. Treatment-group differences in continuous measures were compared using an analysis-of-variance model containing terms for treatment and investigator. Treatment-group differences in categorical measures were compared using Fisher’s exact test.
AISRS – Adult ADHD Investigator Symptom Rating Scale; ASRS – Adult ADHD Self-Report Scale; NA – not available; OCDS – Obsessive Compulsive Drinking Scale; SD-standard deviation.