Table 3.
Change from baseline to Visit 14 (end of double-blind phase) in drinks per day and AISRS total score stratified by baseline duration of sobriety.
| Baseline Duration of Sobriety
|
Compare Sobriety. Group (p-value) | ||||||
|---|---|---|---|---|---|---|---|
| ≤4 consecutive days | >4 consecutive days | ||||||
|
| |||||||
| ATX (n = 17) | Placebo (n = 23) | Total (n = 40) | ATX (n = 15) | Placebo (n = 25) | Total (n = 40) | ||
| Drinks per day Baseline Mean (SD) | 2.25 (1.31) | 3.29 (2.51) | 2.85 (2.13) | 1.97 (1.23) | 1.93 (1.45) | 1.94 (1.36) | 0.0566 |
| Drinks per day Change from baseline to V14 Mean(SD) | 0.41 (2.51) | 0.49 (2.55) | 0.45 (2.49) | 0.19 (1.66) | 0.71 (2.01) | 0.51 (1.88) | 0.6602 |
| AISRS, Baseline Mean (SD) | 39.65 (7.01) | 40.43 (7.79) | 40.10 (7.38) | 38.93 (9.12) | 39.12 (7.08) | 39.05 (7.79) | 0.4221 |
| AISRS, Change from baseline to V14 Mean (SD) | −20.53 (11.32) | −12.70 (13.67) | −16.03 (13.16) | −13.27 (11.04) | −6.44 (10.02) | −9.00 (10.80) | 0.0790 |
| ASRS, Baseline Mean (SD) | 44.47 (8.59) | 49.04 (9.14) | 47.10 (9.09) | 50.60 (8.35) | 51.16 (9.39) | 50.95 (8.91) | 0.0781 |
| ASRS, Change from baseline to V14 Mean (SD) | −17.35 (9.43) | −12.78 (16.21) | −14.73 (13.78) | −17.00 (13.85) | −7.64 (11.51) | −11.00 (13.04) | 0.5821 |
ADHD – attention-deficit/hyperactivity disorder; AISRS – Adult ADHD Investigator Symptom Rating Scale; ATX – atomoxetine; SD – standard deviation; V14–Visit 14.