Fig. 1.
OGD decreases PC GABAA receptor sensitivity to etomidate. (A) Representative recordings from cultured PCs illustrating responses to 1 s applications of 5 µm GABA plus 0.3, 1, 3, 5, or 10 µm etomidate (bars above trace indicate application). (B) Average concentration-response relationships for etomidate from control and OGD PCs. The average EC50 for control cells was 2.9 ± 0.3 µm. The OGD cell average EC50 was 3.8 ± 0.2 µm (P < 0.05). Data presented are the average of eight control cells and six OGD cells.
