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OGD does not affect PC GABAA receptor sensitivity to propofol. (A) Representative recordings from cultured PCs illustrating responses to 1 s applications of 2 µm GABA plus 1, 3, 5, 10, or 15 µm propofol (bars above trace indicate application). (B) Average concentration-response relationships for propofol from control and OGD PCs. The average EC50 for control cells was 5.6 ± 0.5 µm (n = 9). The OGD cell EC50 was 5.8 ± 0.5 µm (n = 12).
