Table 1.
PC GABAA receptor sensitivity to subunit-specific positive modulators
| Drug | Subunit | Control EC50 | OGD EC50 | Control vs. OGD P < 0.05 |
|---|---|---|---|---|
| Etomidate | β2–3 | 2.9 ± 0.3 µm (8) | 3.8 ± 0.2 µm (6) | * |
| Propofol | β1–3 | 5.6 ± 0.5 µm (9) | 5.8 ± 0.5 µm (12) | – |
| Zolpidem | α1, γ2 | 466.1 ± 75.8 nm (9) | 491.5 ± 55.6 nm (8) | – |
| Diazepam | α1,2,3,5, γ | 2.3 ± 0.4 µm (7) | 2.8 ± 0.3 µm (7) | – |
Note significant change in sensitivity to etomidate. Numbers inside parentheses indicate number of cells/condition. Summary of PC sensitivities to various drugs before and after OGD. Value are given as the mean ± SEM.
Significant difference.