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. Author manuscript; available in PMC: 2013 Sep 13.

Published in final edited form as: Int J Radiat Biol. 2011 Jul 5;87(10):1052–1060. doi: 10.3109/09553002.2011.587860

CBZ provides protection (A) and mitigation (B) if administered up to 24 hours before or 12 hours after irradiation. A) C57BL/6NTac female mice were injected IP with 10 mg/kg of CBZ 10 min or 24 hrs before 9.25 Gy TBI. B) Mice were injected with CBZ 10 min, 12 hrs or 24 hrs after 9.25 Gy TBI (N = 15 to 30 mice per group). CBZ resulted in significantly increased survival following irradiation if injected 24 hrs or 10 min before irradiation, or 10 min or 12 hrs after irradiation. The p values are in comparison to the radiation only group. C) DMF of CBZ delivered after each of 6 TBI doses. D) Effect of CBZ delivered after greater than or equal to 10.5 Gy TBI. Survival of mice receiving 10.5 Gy + CBZ was not significantly different than survival of mice receiving 9.5 Gy irradiation only (p < 0.05). Dividing 10.5 Gy by 9.25 Gy resulted in a DMF of 1.13.

CBZ provides protection (A) and mitigation (B) if administered up to 24 hours before or 12 hours after irradiation. A) C57BL/6NTac female mice were injected IP with 10 mg/kg of CBZ 10 min or 24 hrs before 9.25 Gy TBI. B) Mice were injected with CBZ 10 min, 12 hrs or 24 hrs after 9.25 Gy TBI (N = 15 to 30 mice per group). CBZ resulted in significantly increased survival following irradiation if injected 24 hrs or 10 min before irradiation, or 10 min or 12 hrs after irradiation. The p values are in comparison to the radiation only group. C) DMF of CBZ delivered after each of 6 TBI doses. D) Effect of CBZ delivered after greater than or equal to 10.5 Gy TBI. Survival of mice receiving 10.5 Gy + CBZ was not significantly different than survival of mice receiving 9.5 Gy irradiation only (p < 0.05). Dividing 10.5 Gy by 9.25 Gy resulted in a DMF of 1.13.