Table I.

Effects of Carbamazepine on 32D cl 3 Cell Clonogenic Radiation Survival

Drug Concentration Added	D0 (Gy)	ñ
Control	1.5 ± 0.1	1.5 ± 0.3
1 μM Before Irradiation	2.1 ± 0.2 (p = 0.012)	1.0 ± 0.1
1 μM After Irradiation	1.6 ± 0.2	10.1 ± 4.2 (p = 0.011)
10 μM Before Irradiation	2.3 ± 0.1 (p = 0.010)	1.0 ± 0.1
10 μM After Irradiation	1.2 ± 0.1	5.5 ± 1.7 (p = 0.019)
100 μM Before Irradiation	3.6 ± 0.7 (p = 0.003)	1.0 ± 0.1
100 μM After Irradiation	1.3 ± 0.8	3.6 ± 0.8 (p = 0.014)
Glyburide 10 μM Before Irradiation (Jiang et al. 2009)	1.1 ± 0.2	34.9 ± 0.5 (p = 0.002)

Four-well plates with 500 or 1000 cells per plate were scored at day 7 for colonies of ≥ 50 cells as described in Materials and Methods. Drugs were dissolved DMSO as described in the Methods. The p values compare each drug concentration above to non-drug treated irradiated cells using the SHMT model (Epperly et al. 2003). DMSO (< 1%) was added to control irradiated cultures and had no effect on the radiation survival compared to irradiation alone.