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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Nature. 2008 Nov 2;457(7230):722–725. doi: 10.1038/nature07537

Figure 3. Tonsil NKp44+ NK cells produce IL-22, IL-26 and LIF. IL-23 and TLR-activated monocytes trigger IL-22 secretion.

Figure 3

a, IL-22 concentration in supernatants of NKp44+ and NKp44− tonsil NK cells stimulated with PMA/ionomycin. b, Intracellular IL-22 and LIF content of tonsil NKp44+ cells and blood NK cells stimulated with PMA/ionomycin. c, NKp44+ NK cells express higher levels of IL-26 mRNA than NKp44− NK cells. d-e, IL-23 triggers secretion of IL-22 (d, e) but not IL-17 (e) by NK-22 cells. MFI, mean fluorescence intensity. f, NKp44+ NK cells produce IL-22 in response to IL-23 and, to some extent, IL-15. NKp44− NK cells release IFN-γ in response to IL-12 or IL-15. g, Monocytes stimulated with resiquimod and LPS induce IL-22 secretion in NK-22 cells. All error bars indicate s.d. with n=3