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. Author manuscript; available in PMC: 2013 Sep 13.
Published in final edited form as: Nature. 2008 Nov 2;457(7230):722–725. doi: 10.1038/nature07537

Figure 4. NK-22 cell-secreted cytokines stimulate epithelial cells to proliferate, release IL-10 and activate STAT1 and STAT3.

Figure 4

a, Colo205 proliferation in response to supernatants derived from resting or IL-23-stimulated tonsil NK cells (left panel) or IL-22 (right panel). b, IL-10 secretion by Colo205 stimulated with supernatants from activated NKp44+ or NKp44− tonsil NK cells or IL-22. c, STAT3 and STAT1 phosphorylation in Colo205 stimulated with supernatants of IL-23-activated NKp44+ NK cells (left panels, grey histograms), NKp44− NK cells (left panels, empty histograms), IL-22 (right panels, grey histograms) or medium (right panels, empty histograms). As an additional control for STAT1 phosphorylation, cells were stimulated with IFN-γ (dotted line). All error bars indicate s.d. with n=3